Pair Name	Aloe emodin, Gefitinib
Disease Info	[ICD-11: 2C25.Z]	Lung cancer		Investigative
Biological Phenomena	Inhibition-->Epithelial-mesenchymal transition
Gene Regulation	Down-regulation	Expression	SLC22A3	hsa6581
	Down-regulation	Expression	PIK3CA	hsa5290
	Down-regulation	Expression	AKT1	hsa207
In Vitro Model	PC-9	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_B260
	PC-9-GR-high	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_S706
In Vivo Model	After acclimated for one week, subcutaneous inoculation of 1×10⁷ PC9-GR cells was executed into the right flank of the animals (n = 4 in each group) to develop xenograft models.
Result	AE could enhance the gefitinib sensitivity of PC9-GR cells and reverse EMT by blocking PI3K/Akt/TWIS1 signal pathway.